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Surge in Early-Onset Breast Cancer Linked to Plasticizers
pine Webmaster of Pineapple
2014/07/08 04:15
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Reporter Zhan Jianfu, Yang Xinjie / Taipei Report | United Daily News – July 8, 2014

The plasticizer scandal that swept Taiwan in 2011 revealed that plasticizers were almost omnipresent, from tea drinks and juices to sports beverages, as well as capsule or tablet-form health supplements. Research from Academia Sinica has confirmed that the increasing prevalence of younger breast cancer patients in Taiwan and the high rate of estrogen receptor positivity are linked to plasticizers.

Cancer has topped the list of the top ten causes of death for 32 consecutive years. For the first time, the United Daily News Group and Academia Sinica are jointly hosting the "Health Summit Forum," with the theme "A New Future for Personalized Cancer Prevention," to share the latest information on cancer research. The first session, held on the morning of July 19, will feature Deputy Director Chen Chien-jen of Academia Sinica presenting joint research findings with the National Health Research Institutes, unveiling the latest discoveries on breast cancer.

Chen Chien-jen pointed out that epidemiological statistics show breast cancer in Taiwanese women has an "early-onset" characteristic. About half of young breast cancer cases have no known exposure to risk factors. Through case-control studies, it has been confirmed that di(2-ethylhexyl) phthalate (DEHP) in plasticizers stimulates estrogen secretion and increases the risk of breast cancer.

Breast cancer is the most common cancer among women worldwide, with approximately 1.67 million women diagnosed annually. Compared to Europe and the U.S., Taiwan is considered a low-incidence region for breast cancer, but the incidence rate has surged 5.4 times over the past 30 years, with half of cases occurring before menopause, showing an "early-onset" trend.

Compared to young breast cancer patients in Western countries, young Taiwanese patients exhibit significantly higher rates of estrogen receptor (ER) positivity, which appears to be related to excessive estrogen exposure. Besides being synthesized in the body, estrogen-like substances in the environment, known as environmental hormones, also play a role. Plasticizers are a major source of these environmental hormones.

Di(2-ethylhexyl) phthalate (DEHP) has been classified by the International Agency for Research on Cancer as a Group 2B possible carcinogen. The research team found that the concentration of DEHP metabolite mono(2-ethylhexyl) phthalate (MEHP) in the urine of breast cancer patients was significantly higher than in the control group, suggesting that plasticizers may further catalyze breast cancer development.

The 2014 Health Summit Forum is scheduled for July 19 and 20 at the National Taiwan University's Lin Ze Hall International Conference Center. Nine academic and medical experts will provide the latest research insights on four major cancers: lung, breast, liver, and stomach cancer.

Organizers: United Daily News, Academia Sinica
Sponsor: Roche Pharmaceuticals

Source: https:/ / tw. news. yahoo. com/ % E……6% 8D% E9% A6% 96- 195500058. html
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