Clipping Board » Drug Poisoning ─ It is necessary to be aware of the toxic side effects before taking medication.
The Department of Pharmaceutical Affairs under the Executive Yuan's Department of Health announced today that strong painkillers containing Ketorolac, commonly used post-surgery (such as Ketorolac tablets and 26 other oral, injectable, and eye drop medications), may cause anaphylactic shock and even fatal reactions. As a result, manufacturers of Ketorolac-containing drugs have been required to add warning labels to their product inserts, reminding healthcare professionals to use these medications with caution.
Liao Jizhou, Director of the Department of Pharmaceutical Affairs, pointed out that Ketorolac-based painkillers are widely used in the medical field for strong post-surgical pain relief. To date, Taiwan has reported seven cases of anaphylactic shock following the injection of Ketorolac-containing medications, four of which resulted in death. Consequently, the Department of Pharmaceutical Affairs convened a meeting with experts and scholars to discuss the risk-benefit profile of Ketorolac-containing drugs.
Liao Jizhou stated that after discussions, experts generally agreed that Ketorolac-containing drugs remain clinically important for pain management. With careful and cautious use, adverse reactions can be prevented. It was decided that manufacturers must add warning labels to the product inserts, alerting healthcare professionals to the fact that Ketorolac-containing drugs have been associated with fatal anaphylactic shock cases. When using Ketorolac, emergency equipment should be prepared in advance, and patients should be monitored for safety within 30 minutes after injection.
Additionally, to prevent healthcare professionals from mistakenly using Ketorolac-containing drugs to reduce fever or lower body temperature, the Department of Pharmaceutical Affairs has also required that the product inserts include warnings against using these medications for fever reduction.
Source: http://www. udn. com/ 2008/ 1/ 10/ NEWS/ HEALTH/ HEA1/ 4175192. shtml
United Daily News / Reporter Chen Huihui / Taipei Report 2008.01.11 05:38 am
Anti-inflammatory injections containing Ketorolac, commonly used for pain relief post-surgery, are suspected to have caused anaphylactic shock in seven patients, four of whom died. The Department of Health yesterday reminded physicians to use this medication cautiously, requiring that emergency equipment be available when using this injection, and prohibiting its use for fever reduction.
Anti-inflammatory painkillers containing Ketorolac, including 26 types such as Daowutong tablets, Keduoyan film-coated tablets, and Yangtongning injections, come in three forms: oral, injectable, and eye drops. As they are generic drugs with expired patents, they are relatively inexpensive and have good pain-relieving effects, making them widely used in medical institutions.
The Department of Health's Pharmaceutical Affairs Division has requested that pharmaceutical companies add warning labels to the instructions of related oral and injectable medications by April 10. Some surgeons have noted that, besides anaphylactic shock, the most common side effect is stomach irritation, and it is best avoided by those with weak stomachs or elderly patients.
Data from the Department of Health's Adverse Drug Reaction Reporting Center shows that over the past decade, seven patients experienced a sharp drop in blood pressure and anaphylactic shock after being injected with Ketorolac-containing non-steroidal anti-inflammatory drugs, four of whom died. Liao Jizhou, director of the Pharmaceutical Affairs Division, said the most recent death involved a 28-year-old male who died from a severe allergic reaction after receiving a Ketorolac-containing drug for pain relief following ENT surgery. In the previous year's list of the top ten suspected drugs for adverse reactions, Ketorolac-containing anti-inflammatory drugs ranked third, with 124 reported cases.
Liao Jizhou stated that some doctors believe non-steroidal anti-inflammatory drugs can both relieve pain and reduce fever, but in fact, while these drugs are effective for pain relief, they are not effective for fever reduction. Additionally, the Department of Health requires that hospitals using Ketorolac-containing injections have emergency equipment and monitor patients for safety for half an hour after injection. Liao emphasized that if a patient is allergic to Ketorolac, immediate treatment with adrenaline can significantly reduce mortality.
Yan Zhengyou, director of the Joint Reconstruction Department at I-Shou University Hospital, said that nearly half of orthopedic surgery patients use this drug for pain relief, and it is occasionally used for fever reduction. He noted that many drugs can cause anaphylactic shock, but the key is to ensure proper post-operative monitoring. More commonly, the side effect is stomach irritation, so it should not be used in patients with weak stomachs or the elderly. Ke Shaohua, a neurosurgeon at Cathay General Hospital, said he no longer uses this drug due to reported adverse reactions.
Source: http://udn. com/ NEWS/ HEALTH/ HEA1/ 4175852. shtml
Painkillers Like Ketoprofen Carry Risks, Labels Warn
Liao Jizhou, Director of the Department of Pharmaceutical Affairs, pointed out that Ketorolac-based painkillers are widely used in the medical field for strong post-surgical pain relief. To date, Taiwan has reported seven cases of anaphylactic shock following the injection of Ketorolac-containing medications, four of which resulted in death. Consequently, the Department of Pharmaceutical Affairs convened a meeting with experts and scholars to discuss the risk-benefit profile of Ketorolac-containing drugs.
Liao Jizhou stated that after discussions, experts generally agreed that Ketorolac-containing drugs remain clinically important for pain management. With careful and cautious use, adverse reactions can be prevented. It was decided that manufacturers must add warning labels to the product inserts, alerting healthcare professionals to the fact that Ketorolac-containing drugs have been associated with fatal anaphylactic shock cases. When using Ketorolac, emergency equipment should be prepared in advance, and patients should be monitored for safety within 30 minutes after injection.
Additionally, to prevent healthcare professionals from mistakenly using Ketorolac-containing drugs to reduce fever or lower body temperature, the Department of Pharmaceutical Affairs has also required that the product inserts include warnings against using these medications for fever reduction.
Source: http://www. udn. com/ 2008/ 1/ 10/ NEWS/ HEALTH/ HEA1/ 4175192. shtml
Four Patients Die after Ketorolac Injection for Pain Relief
Anti-inflammatory injections containing Ketorolac, commonly used for pain relief post-surgery, are suspected to have caused anaphylactic shock in seven patients, four of whom died. The Department of Health yesterday reminded physicians to use this medication cautiously, requiring that emergency equipment be available when using this injection, and prohibiting its use for fever reduction.
Anti-inflammatory painkillers containing Ketorolac, including 26 types such as Daowutong tablets, Keduoyan film-coated tablets, and Yangtongning injections, come in three forms: oral, injectable, and eye drops. As they are generic drugs with expired patents, they are relatively inexpensive and have good pain-relieving effects, making them widely used in medical institutions.
The Department of Health's Pharmaceutical Affairs Division has requested that pharmaceutical companies add warning labels to the instructions of related oral and injectable medications by April 10. Some surgeons have noted that, besides anaphylactic shock, the most common side effect is stomach irritation, and it is best avoided by those with weak stomachs or elderly patients.
Data from the Department of Health's Adverse Drug Reaction Reporting Center shows that over the past decade, seven patients experienced a sharp drop in blood pressure and anaphylactic shock after being injected with Ketorolac-containing non-steroidal anti-inflammatory drugs, four of whom died. Liao Jizhou, director of the Pharmaceutical Affairs Division, said the most recent death involved a 28-year-old male who died from a severe allergic reaction after receiving a Ketorolac-containing drug for pain relief following ENT surgery. In the previous year's list of the top ten suspected drugs for adverse reactions, Ketorolac-containing anti-inflammatory drugs ranked third, with 124 reported cases.
Liao Jizhou stated that some doctors believe non-steroidal anti-inflammatory drugs can both relieve pain and reduce fever, but in fact, while these drugs are effective for pain relief, they are not effective for fever reduction. Additionally, the Department of Health requires that hospitals using Ketorolac-containing injections have emergency equipment and monitor patients for safety for half an hour after injection. Liao emphasized that if a patient is allergic to Ketorolac, immediate treatment with adrenaline can significantly reduce mortality.
Yan Zhengyou, director of the Joint Reconstruction Department at I-Shou University Hospital, said that nearly half of orthopedic surgery patients use this drug for pain relief, and it is occasionally used for fever reduction. He noted that many drugs can cause anaphylactic shock, but the key is to ensure proper post-operative monitoring. More commonly, the side effect is stomach irritation, so it should not be used in patients with weak stomachs or the elderly. Ke Shaohua, a neurosurgeon at Cathay General Hospital, said he no longer uses this drug due to reported adverse reactions.
Source: http://udn. com/ NEWS/ HEALTH/ HEA1/ 4175852. shtml