Clipping Board » Illness Enters through Mouth ─ The information that has been made public is often just the tip of the iceberg...
Reporter Chen Yuxin / Taipei Report | July 18, 2020
A collaborative study by Academia Sinica and National Taiwan University Hospital has identified "APOBEC mutation" as the primary cause of lung cancer in non-smokers. While the exact cause of the mutation remains unclear, the team compared five newly discovered cancer cell mutation signatures with international carcinogenic mutation databases, pinpointing three potential substances. The findings suggest that lung cancer risk factors extend beyond air pollution or cooking fumes to include dietary additives and preservatives.
Additionally, the study found that women under 60 are more affected by APOBEC mutations, whereas those over 60 are more influenced by long-term environmental factors such as air pollution and secondhand smoke. This indicates that reducing exposure to carcinogens in daily life could be an effective strategy for lung cancer prevention.
Dr. Pan-Chyr Yang, a professor of internal medicine at NTU College of Medicine, stated that future lung cancer prevention efforts should not rely solely on smoking cessation but must also address diet, environment, genetics, lifestyle, medication, and aging. Dr. Jin-Shing Chen, director of thoracic surgery at NTU Hospital, added that the discovery of dietary factors like food additives as potential lung cancer causes will influence future health education approaches.
Dr. Hsuan-Yu Chen, an associate research fellow at Academia Sinica’s Institute of Statistical Science, explained that cell mutations produce consistent patterns, known as "cancer fingerprints." While international databases exist for such signatures, Taiwan has yet to establish one. By comparing the five mutation signatures with global databases, the team identified possible risk factors.
The study revealed three substances linked to the five mutation signatures: nitrosamines (e.g., preservatives and food additives), polycyclic aromatic hydrocarbons (PAHs, e.g., secondhand smoke and combustion fumes), and nitro-polycyclic aromatic hydrocarbons (Nitro-PAHs, e.g., PM2.5 and vehicle emissions). Other potential carcinogens include aflatoxins, nicotine, and formaldehyde.
Dr. Yu-Ju Chen, director of Academia Sinica’s Institute of Chemistry, noted that beyond smoking and secondhand smoke, factors like water, processed foods, vehicle emissions, and air pollution show associations with lung cancer. Further research is needed to confirm which factors are key drivers of carcinogenic genes in Taiwanese patients.
Using proteomic profiling, the research team classified lung cancer into five subtypes, including a previously unidentified "early-stage but late-like" subtype characterized by dual mutations and elevated MMP11 protein levels. Dr. Chen suggested that MMP11 could serve as a biomarker for early detection tools in the future.
Source: https:/ / tw. news. yahoo. com/ % E……E% 86% E7% 9A% 84- 224920754. html
Food Additives, Preservatives... Taiwanese Lung Cancer May be Diet-Related
A collaborative study by Academia Sinica and National Taiwan University Hospital has identified "APOBEC mutation" as the primary cause of lung cancer in non-smokers. While the exact cause of the mutation remains unclear, the team compared five newly discovered cancer cell mutation signatures with international carcinogenic mutation databases, pinpointing three potential substances. The findings suggest that lung cancer risk factors extend beyond air pollution or cooking fumes to include dietary additives and preservatives.
Additionally, the study found that women under 60 are more affected by APOBEC mutations, whereas those over 60 are more influenced by long-term environmental factors such as air pollution and secondhand smoke. This indicates that reducing exposure to carcinogens in daily life could be an effective strategy for lung cancer prevention.
Dr. Pan-Chyr Yang, a professor of internal medicine at NTU College of Medicine, stated that future lung cancer prevention efforts should not rely solely on smoking cessation but must also address diet, environment, genetics, lifestyle, medication, and aging. Dr. Jin-Shing Chen, director of thoracic surgery at NTU Hospital, added that the discovery of dietary factors like food additives as potential lung cancer causes will influence future health education approaches.
Dr. Hsuan-Yu Chen, an associate research fellow at Academia Sinica’s Institute of Statistical Science, explained that cell mutations produce consistent patterns, known as "cancer fingerprints." While international databases exist for such signatures, Taiwan has yet to establish one. By comparing the five mutation signatures with global databases, the team identified possible risk factors.
The study revealed three substances linked to the five mutation signatures: nitrosamines (e.g., preservatives and food additives), polycyclic aromatic hydrocarbons (PAHs, e.g., secondhand smoke and combustion fumes), and nitro-polycyclic aromatic hydrocarbons (Nitro-PAHs, e.g., PM2.5 and vehicle emissions). Other potential carcinogens include aflatoxins, nicotine, and formaldehyde.
Dr. Yu-Ju Chen, director of Academia Sinica’s Institute of Chemistry, noted that beyond smoking and secondhand smoke, factors like water, processed foods, vehicle emissions, and air pollution show associations with lung cancer. Further research is needed to confirm which factors are key drivers of carcinogenic genes in Taiwanese patients.
Using proteomic profiling, the research team classified lung cancer into five subtypes, including a previously unidentified "early-stage but late-like" subtype characterized by dual mutations and elevated MMP11 protein levels. Dr. Chen suggested that MMP11 could serve as a biomarker for early detection tools in the future.
Source: https:/ / tw. news. yahoo. com/ % E……E% 86% E7% 9A% 84- 224920754. html