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Huang Shengzhu / Text 2018-05-28
Inflammatory responses are often associated with changes in body temperature, but the role of temperature in inflammation has been difficult to confirm through research. Recently, a study published in *PNAS* (*Proceedings of the National Academy of Sciences*) by a team of scientists from the University of Warwick and the University of Manchester, among others, found that "the higher the body temperature, the faster the body activates key defense systems against cancer, wounds, and infections!"
The Switch That Activates Immune Responses—NF-κB
NF-κB, also known as "nuclear factor kappa B," is a protein complex that controls DNA transcription and is present in all types of animal cells. When cells are exposed to bacteria, viruses, free radicals, ultraviolet radiation, or especially when an immune response is triggered, NF-κB participates in regulatory functions.
The study found that during fever, inflammatory signals can activate and accelerate the switching function of NF-κB. The NF-κB protein complex was observed moving in and out of the cell nucleus during immune responses, turning genes on or off to help cells respond appropriately to inflammation, infection, or cancer. However, when NF-κB becomes dysregulated, inflammatory conditions such as Crohn's disease, psoriasis, and rheumatoid arthritis can occur.
Research Confirms Body Temperature Regulates Immune Responses
Experiments on mice showed that body temperature significantly affects immune responses. Lower body temperature during sleep made cancer cells more likely to spread, explaining why shift work, sleep disorders, and jet lag—which lower body temperature—increase the risk of immune-related diseases. When body temperature drops to 34°C, NF-κB switching slows down, whereas when it rises above the normal 37°C, such as during a fever, NF-κB switching speeds up.
The study demonstrated that temperature changes alter inflammatory responses in cells and tissues through biological mechanisms. This also explains why lower respiratory tract temperatures make individuals more susceptible to rhinovirus infections—immune responses weaken at lower temperatures. The findings align with real-world observations that cold winters exacerbate flu outbreaks. Additionally, mice living in high-temperature environments showed lower rates of immune-related diseases and cancer, further supporting the idea that different body temperatures can modulate immune responses.
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Scientists Confirm: Body Temperature Controls Cellular Immune Response
Inflammatory responses are often associated with changes in body temperature, but the role of temperature in inflammation has been difficult to confirm through research. Recently, a study published in *PNAS* (*Proceedings of the National Academy of Sciences*) by a team of scientists from the University of Warwick and the University of Manchester, among others, found that "the higher the body temperature, the faster the body activates key defense systems against cancer, wounds, and infections!"
The Switch That Activates Immune Responses—NF-κB
NF-κB, also known as "nuclear factor kappa B," is a protein complex that controls DNA transcription and is present in all types of animal cells. When cells are exposed to bacteria, viruses, free radicals, ultraviolet radiation, or especially when an immune response is triggered, NF-κB participates in regulatory functions.
The study found that during fever, inflammatory signals can activate and accelerate the switching function of NF-κB. The NF-κB protein complex was observed moving in and out of the cell nucleus during immune responses, turning genes on or off to help cells respond appropriately to inflammation, infection, or cancer. However, when NF-κB becomes dysregulated, inflammatory conditions such as Crohn's disease, psoriasis, and rheumatoid arthritis can occur.
Research Confirms Body Temperature Regulates Immune Responses
Experiments on mice showed that body temperature significantly affects immune responses. Lower body temperature during sleep made cancer cells more likely to spread, explaining why shift work, sleep disorders, and jet lag—which lower body temperature—increase the risk of immune-related diseases. When body temperature drops to 34°C, NF-κB switching slows down, whereas when it rises above the normal 37°C, such as during a fever, NF-κB switching speeds up.
The study demonstrated that temperature changes alter inflammatory responses in cells and tissues through biological mechanisms. This also explains why lower respiratory tract temperatures make individuals more susceptible to rhinovirus infections—immune responses weaken at lower temperatures. The findings align with real-world observations that cold winters exacerbate flu outbreaks. Additionally, mice living in high-temperature environments showed lower rates of immune-related diseases and cancer, further supporting the idea that different body temperatures can modulate immune responses.
https:/ / heho. com. tw/ archives……dium=heho& utm_campaign=click